Homocysteine accelerates hepatocyte autophagy by upregulating TFEB via DNMT3b-mediated DNA hypomethylation
Autophagy plays a critical role in the waist deep dvd physiology and pathophysiology of hepatocytes.High level of homocysteine (Hcy) promotes autophagy in hepatocytes, but the underlying mechanism is still unknown.Here, we investigate the relationship between Hcy-induced autophagy level and the expression of nuclear transcription factor EB (TFEB).T